ACUSURGICAL (Montpellier, Hérault, Occitanie, France) is developing a robotic assistant for vitreo-retinal surgery to the treatment of retinal diseases such as age-related macular degeneration. Our mission is to improve the precision and safety of current retinal procedures, augmenting the surgeons abilities and thus enabling new retinal surgeries. The aim is to treat the significative percentage of patients who today suffer from limited treatment options.

Therapeutic: Robotics

Francois Laborde

Chief Medical Officer

Affluent Medical is a French player in MedTech, founded by Truffle Capital, with the aim of becoming a global leader in the treatment of heart and vascular diseases, which are the leading cause of death worldwide, and of urinary incontinence, which today affects one in four adults. Affluent Medical develops innovative, next-generation minimally invasive implants to restore essential physiological functions in these areas. The four major technologies developed by the Company are currently in the preclinical and clinical study phase. The first medical device should be marketed in Europe with Kalios.

Therapeutic: Cardiology and Urology

AtriAN Medical (Galway, Ireland) is in preparation for first-in-human trials for treating Atrial Fibrillation (AFib) with a novel non-thermal approach using technology first explored by world-renowned clinicians in Mayo Clinic. AtriAN's technology uses specialized catheters delivering short pulses of low energy electrical fields to discrete sites of autonomic hyperactivity located on the outside surface of the heart. This selectively ablates these autonomic neuronal structures, providing a long-term resolution to AFib. AtriAN is an Irish company, based in Galway.

Therapeutic: Cardiovascular

ATRO Medical (Nijmegen, The Netherlands) is a Dutch startup, founded in 2017. ATRO Medical has developed its second generation of the Trampoline meniscus prosthesis. The device is indicated for patients with persistent knee pain and failed conservative therapies. The anatomical shaped polymer based meniscus replaces the damaged meniscus, to reduce pain and improve patient mobility. ATRO Medical is, next to the medical meniscus, actively seeking funding for the development of a unique lateral meniscus prosthesis.

Therapeutic: Orthopedics-Spine

Almog Aley-raz

CEO & VP R&D

CorNeat Vision (Ra'anana, Israel) is a clinical-stage biomimetic implants and technology company. Originally set up as an artificial cornea company, the CorNeat Vision team researched ways to integrate artificial optics with resident ocular tissue. Serendipitously they developed a generic implant material technology: The EverMatrix™. EverMatrix™ is a disruptive nondegradable synthetic “ECM” that embeds with live tissue for life! It enables a new era of implants that bio-mechanically integrate with surrounding tissue, permanently reinforce soft tissue, provide membrane for tissue regeneration, and more.

Therapeutic: Biomaterials

Yuval Mandelbaum

CEO

Discure Technologies (Herzliya, Israel) is a venture-backed startup, developing a minimally invasive device designed to treat and reverse degenerative disc disease (DDD), reducing pain and restoring functionality to patients. The system is designed to eliminate the need for invasive surgery and reduce the use of opioids. The company received Breakthrough Device Designation from FDA in 2021, and was selected as the “Best New Technology in Spine Care – 2021”, by a distinguished panel of US orthopedic surgeons and neurosurgeons.

Therapeutic: Orthopedics-Spine

Echopoint Medical (London, UK) is a spin-out from UCL, London, commercialising a series of novel optical sensing technologies. The first will be the iKOr™ Rx coronary microcatheter, delivered over any workhorse 0.014” guidewire to provide pressure (FFR, resting indices) and flow (e.g.CFR, IMR) with a solid-state sensor (no saline injection). The extreme low-profile microcatheter, straightforward console UI plus workflow provides key metrics with a negligible training requirement.

Therapeutic: Cardiovascular & Interventional Cardiology

ElectroPhysiology Frontiers (Milan, Italy) is an early stage MedTech company actively developing a safe, innovative, and easy to use “single shot” Pulsed-Field Ablation (PFA) system to provide more long-lasting and durable treatment for Atrial Fibrillation

Therapeutic: Cardiovascular

E-Scopics S.A.S (Aix-en-Provence, France) E-Scopics dematerializes Ultrasound to democratize its use to all healthcare professionals. Products are application specific Apps, downloadable on Tablets or Smartphones that connect to, and control smart digital probes. E-Scopics truly revolutionizes the field of Ultrasound, leveraging advance processing techniques and AI-based imaging algorithms. This allows ultra-low power consumption systems, addressing the key issue of all ultraportable systems on the market. E-Scopics further differentiates clinically with unique “imaging biomarkers” that standardize surveillance of chronic diseases, without acquisition skills nor interpretation expertise.

Therapeutic: Imaging & Diagnostics

Matthieu De Beule

CEO & Co-founder

FEops HEARTguide (Gent, Belgium), currently available on the EU and Canadian market, is a one-in-its-kind cloud based procedure planning environment for structural heart interventions that provides physicians unique insights to evaluate device sizing and positioning pre-operatively using novel computational modeling and simulation technology. Such insights have the power to help improving clinical outcomes in real-world hospital settings. The current release includes workflows for transcatheter aortic valve implantation (TAVI) and left atrial appendage occlusion (LAAo) procedures.

Therapeutic: Cardiovascular

Robert Perryman

CEO

The Audicor Remote Heart Failure Management System by Inovise Medical (Portland, Oregon, USA) is non-invasive solution that provides actionable feedback to the clinician, which is clinically proven to enhance patient outcomes and reduce costs as compared with existing methods.

Therapeutic: Remote Patient Monitoring

Benjamin Hertzog

CEO

Using wireless electronics to stimulate healing. Intelligent Implants is at the forefront of electrotherapeutic devices to treat disease and aid recovery in bone and other tissues. We pioneer the use of data, engineering, and medicine to bring novel, active and connected medical devices to healthcare. Our integrated devices facilitate treatment for the patient, as well as, decision making for the healthcare professional. Our devices can monitor progress, allowing physicians to make smarter decisions during the course of treatment. Access to information reduces the risk for the patient, cutting down the chance of serious complications and shortening the length of treatment.

Therapeutic: Orthopedics

Stephen Cox

CEO

InVera Medical (Galway, Ireland) is developing a less-invasive, effective, pain-free and faster minimally invasive endovenous medical device treatment for ineffective circulation known as chronic venous disease.

The InVera™ device is the world’s first effective non-thermal medical device to cure varicose vein and venous ulcer symptoms of chronic venous disease. InVera™ uses the body’s natural healing response to cure symptoms allowing all chronic venous disease sufferers receive treatment for the first time.

Therapeutic: Cardiovascular

Claire Woodthorpe

CEO

Lightpoint Medical (Chesham, Buckinghamshire, UK) develops and markets innovative technologies for intra-operative cancer detection. We are driven by the mission to improve the lives of people with cancer by transforming the efficacy of cancer surgery. Our imaging, sensing and AI tools help surgeons to quickly and accurately detect cancer in real-time in the operating room, aiming to enhance surgical precision, improve patient outcomes, and reduce costs for healthcare systems.

Therapeutic: Minimally Invasive Surgery

Loop Medical (Lausanne, Switzerland) The COVID-19 crisis cruelly highlighted the need to improve access to clinical diagnosis. Loop Medical's vision is to simplify access to clinical-grade blood testing for everyone, everywhere, and to unlock the tremendous potential of home testing. We are developing a painless, easy-to-use sampling device that collects a large volume of high-quality capillary blood (1 mL vs. only 0.2 mL for competitors). It is supported by the Bill & Melinda Gates Foundation, by the Horizon 2020 programme and partners with Cerba Healthcare.

Therapeutic: Diagnostics

Antony Rix

CEO

Lucida Medical’s (Cambridge, UK) AI-based software enables radiologists to find cancer precisely and fast, by analysing routine MRI scans. Pi™ (Prostate Intelligence) is CE-marked for prostate cancer and has shown leading accuracy in published data. It is easy to deploy, with integration proven with GE Healthcare and the NHS East Midlands, enabling cost-effective adoption by hospitals. Pi™ meets an urgent need to address scalability, quality and repeatability issues in MRI analysis, and late detection of cancer.

Therapeutic: Imaging

Medical Microinstruments SpA (MMI) (Pisa, Italy) was founded in 2015 to enhance surgical performance through the development of a robotic system that enables surgeons to achieve better outcomes on delicate microsurgical procedures. The MMI robotic platform combines proprietary innovations including the world’s smallest wristed microinstruments as well as tremor-reducing and motion scaling technologies. Together, these powerful capabilities allow more surgeons to successfully perform microsurgery while expanding the field of supermicosurgery.

Therapeutic: Robotics & Surgery

Bryce Klontz

CEO

The VisionPort System platform by New View Surgical (Boston, MA) advances the growth of minimally invasive surgery (MIS) through novel design approaches to surgical visualization that improve clinical care, streamline process, and reduce costs for healthcare systems worldwide.

Therapeutic: Minimally Invasive Surgery

Soukaina Adnane-Murphy

Founder & VP Branding & Communication

Onera Health (Eindhoven, The Netherlands) is a leader in transforming diagnostics and remote monitoring. Our innovative diagnostic solutions and services are poised to help millions of people struggling with health ailments and chronic conditions, ultimately improving the quality of life for patients around the world. The company’s innovative sensors provide comprehensive test data to physicians in a variety of clinical and non-clinical environments to optimize patient care and reduce healthcare costs.

Therapeutics: Diagnostics

Miguel Serrano

CEO

Ophthorobotics was founded in November 2014 and is headquartered in Switzerland. Our team of world class engineers and ophthalmic specialists is passionate about providing a high-tech solution for the delivery of intravitreal injections to treat many chronic ocular diseases.

Therapeutic: Robotics

Abigail Pape

Chief Science Officer

Owl Peak Labs’ (Mclean, Virginia) novel technology application utilizes thermal imaging to give physicians additional information to assist in better identification of problematic lesions in the GI tract and intervene. This imaging capability is designed to be compatible with all existing colonoscopes, but future iterations will integrate it into capsule endoscopy or a pill the patient swallows to survey the intestinal tract. Our AI platform complements the thermal images with rapid, reliable interpretation that augments the physician’s diagnostic and treatment decisions.

Therapeutic: Gastroenterology

Pristine Surgical (Manchester, NH, USA) has developed an integrated surgical imaging system for rigid endoscopy (arthroscopy and laparoscopy) which provides a crystal-clear HD view in a clean, low cost, hassle free single-use device.

Therapeutic: Surgery

Iwan van Vijfeijken

CEO

Pulsify (Leuven, Belgium) is developing the world's first large wearable ultrasound patch for continuous monitoring of cardiac output.

Therapeutic Category: Imaging

Renovos (Southampton, Hampshire, United Kingdom) is transforming regenerative medicine through pioneering use of nanoclay gels from world-class stem cells research. Renovite nanoclays are injectable, bioactive and can deliver and RETAIN biologics within the target site of repair, allowing for significant dose reduction, lower COGS and improved safety of potent biologics. Renovos’ mission is to unlock the full potential of biologics for tissue repair and regeneration with its Renovite platform, and help clinicians deliver safe and more efficacious treatments, addressing a $5.7bn orthobiologics market.

Therapeutic: Biomaterials

RSP Systems (Odense, Funen, Denmark) is a Danish medical technology company focused on bringing innovative glucose monitors to people with diabetes. The all-in-one device uses Raman spectroscopy to painlessly and accurately measure glucose levels in interstitial fluid.

Therapeutic: Diabetes

Karl Blohm

CEO

SafeHeal (Paris, France) develops Colovac, an innovative solution for the protection of colorectal anastomosis. Colovac aims at substituting the need for diverting stoma for patients after colorectal surgery and thereby significantly improves the recovery and QoL of patients, reduces both anastomotic and stoma related complications and reduce cost.

Therapeutics: Surgery

Inovativy Medicina (Lithuania) has developed a robotic system for endovascular procedures - Sentante – a smart, sensory, teleoperated robot system which allows the procedure to be performed remotely, from a different room, thus protecting physicians from harmful X-rays and opening up tele-surgery possibilities. The system senses operators’ movements and provides close to natural haptic force feedback - physicians can feel the catheter and guidewire resistance just as if they were standing near the patient.

Therapeutic: Robotics

Tympany Medical (Galway, Ireland), founded in 2018 by BioInnovate Fellows Dr. Liz McGloughlin and Rory O’Callaghan, has developed a next-generation endoscope platform for ENT surgery that solves unmet needs for patients, surgeons, and healthcare systems. Tympany are advancing the development of their platform endoscope camera technology, which is at the cutting edge of mechanics, optics, electronics and human-centred design. The next generation technology will be designed to transition from the linear to the circular economy, placing Tympany Medical at the heart of sustainable innovation.

Therapeutic: Endoscopy

Dr. Eyal Orion

CEO & Co-Founder

Vectorious Medical Technologies (Tel Aviv, Israel) has developed the V-LAP - the world's first in-heart microcomputer, empowering remote self-management of chronic heart failure patients. The V-LAP platform includes a digital wireless sensor that monitors left atrial pressure and additional valuable information which are available on both patient app and dedicated a physician portal. Following a successful clinical study in 30 patients in Europe, Vectorious completed preparations for a U.S. pivotal study in 2023 to evaluate the first-ever physician-directed patient self-management platform for heart failure patients.

Therapeutic: Cardiovascular

Hubert Thomassen

CEO

Ventinova Medical (Eindhoven, the Netherlands) is a company that develops innovative products for airway management and patient ventilation. Our revolutionary ventilation modes FCV® and EVA® achieve full respiratory control, controlling also the expiration phase. Studies indicate FCV® prevents lung de-recruitment, increases ventilation efficiency and reduces lung damage. FCV® allows ventilation of adults through ultrathin tubes (ID <3 mm) and regular endotracheal tubes via the Evone® Conventional Tube Adapter.

Therapuetic: Respiratory

Denis Harrington

President, Chief Executive Officer

The VentureMed Group (Plymouth, MN, USA) develops endovascular devices to address unmet needs in the treatment of AV fistulas and grafts and peripheral arterial disease. The FLEX Vessel Prep™ System is advancing revascularization through precision vessel preparation utilizing circumferential, long, controlled-depth micro-incisions fundamentally different from balloon inflation products. FLEX micro-incisions improve vessel compliance and enable luminal gain to facilitate final therapy. FLEX was designed to provide Predictable AVF stenosis & peripheral lesion revascularization with minimal complications and sustained outcomes.

Therapeutic: Interventional

Duke Herrell

CMO

The Virtuoso System (Nashville, Tennessee, USA) is a robotic system for rigid endoscopic surgery. The system deploys two tentacle-like arms through a standard, 8.6mm rigid endoscope. Virtuoso's patented system provides the endoscopic surgeon with bi-manual dexterity, precision and force. The system provides two coordinated, interactive surgical tools for retraction, grasping, and energy delivery in the endoscopic surgical lumen -- a heretofore-impossible small scale for this surgical capability.

Therapeutic: Minimally Invasive Surgery

Luca Ravagnan

CEO

WISE (Milan, Italy) is an innovative medical device company developing the new generation of electrodes for Neuromonitoring, Neuromodulation and Brain-Machine Interface using its proprietary Supersonic Technology. The electrodes of WISE are highly ergonomic, conformable, soft and thin, thus allowing a great adhesion, a minimal invasiveness and an excellent adaptability to the nervous tissue. This is possible thanks to the innovative technology of WISE, which allows to produce stretchable, flexible and biocompatible (medical grade) electrodes integrated in extremely thin elastomeric substrates.

Therapeutic: Neuromodulation-Neurostimulation

Stephen Wann

CEO

Zoan BioMed (Connemara, Galway, Ireland) is a highly innovative orthopedics company focused on developing the next generation Bone graft materials from sustainable reared tropical marine coral. We are developing a highly innovative range of products ranging from bone graft substitutes, infection control bone grafts, 3D print bio-materials and replacement allograft struts. Our launch Product ZOANG03, a naturally porous, integrally strong bone graft substitute, is scheduled for FDA 510(k) clearance, fully supported by manufacturing capabilities operating to ISO 13485. Recently announced partnership with BICO / Cellink to develop coral based bio ink and implants.

Therapeutic: Orthopedics