4C Medical Technologies (Brooklyn Park, MN) is focused on minimally invasive therapies for structural heart disease, specifically mitral valve regurgitation.

ATRO Medical (Nijmegen, Netherlands) TRAMMPOLIN (Total ReplAcement of Meniscus with Minimally invasive POLymer ImplaNt) is a synthetic, non‐resorbable total meniscus substitute.

Avectas Ltd (Cambridge, MA) Avectas is an exciting Irish technology company developing Solupore®, a novel vector-free cell engineering technology platform, for intracellular delivery and manufacturing in the immuno-oncology space including CAR-T and gene editing. Solupore® is a novel cell engineering method, based on a proprietary reversible permeabilisation technology, which delivers the cargo in an efficient and gentle manner,  enabling the manufacture of transformative cell therapies while maintaining cell health and functionality.

Beta Bionics (Boston, MA) Our commitment is first and foremost to the community of people living with or affected by diabetes or other conditions of glycemic dysregulation.

Body Vision Medical (Sharon, Israel) offers an innovative LungVision platform, that transforms peripheral lung biopsy into accurate and affordable option, providing substantial clinical benefits. Our solution is powered by artificial intelligence technology to address unmet clinical need for early-stage lung cancer diagnostics and treatment. 

Braster (Warsaw, Poland) developed and commercialised a mHealth system to support women in breast examination. It uses medical device, app and AI to analyse examinations and prepare results.

BriteSeed (Chicago, IL) is an advanced surgery company building smart minimally invasive tools to the operating room that provide imaging of hidden structures, including blood vessels and ureters. These tools use advanced optical hardware and a smart vision engine that has the potential to make surgery safer and faster. Leveraging machine learning and novel hardware, Briteseed will be rolling out the next generation of surgical graspers, vessel sealers, and blunt-tipped dissectors

Carmell Therapeutics (Pittsburgh, PA) has created a unique and highly innovative patented technology based on biologically-active materials manufactured from human blood plasma. Our proprietary process binds and cross-links lyophilized plasma into solid and semi-solid plasma-based materials. These Plasma-based Bioactive Materials (PBMs) contain highly concentrated natural regenerative factors that promote healing in various clinical settings, reduce infections, and, as a result, lower healthcare costs.

Cibiem (Los Altos, CA) has developed a minimally invasive venous catheter system to target the carotid body, a known but unexploited physiologic target that can drive excessive sympathetic nervous system activity in patients with hypertension and heart failure, and has just completed a first-in-human trial in resistant hypertension with promising results. Cibiem’s catheter system uses intravascular ultrasound imaging to guide the procedure and therapeutic ultrasound to ablate the carotid body unilaterally from a venous-only approach.

Conavi Medical (Toronto, Ontario, Canada) is a commercial-stage medical device company that develops image guidance technologies for use in minimally invasive procedures, with an initial focus in cardiology.

CorFlow Therapeutics AG (Baar, Switzerland) is developing the first combined diagnostic and therapeutic medical device for improving microvascular obstructions after a heart attack.

CorWave (Clichy, France) is developing a Left Ventricular Assist Device (LVAD) that offers significant advantages over the currently available devices.

CybeReha (Geneva, Switzerland) – Robotic-assisted muscle electrostimulation leveraging neuronal plasticity in order to restore paraplegic/hemiplegic patients’ sensory-motor loop and improve rehabilitation outcomes.

Day Zero Diagnostics (Allston, MA) is developing a modern approach to the diagnosis of severe infections for an era of rising antibiotic resistance.  We use DNA sequencing and machine learning to rapidly identify an infection and determine its antibiotic susceptibility profile in hours rather than days—saving lives and reducing costs.

Endo Tools Therapeutics (Gosselies, Belgium) develops devices for advanced GI interventions (bariatric surgery, GERD, bypass revision, full thickness resection); devices are CE marked (used in >150 patients, results for bariatrics exceed guidelines); market > USD 5 B.

Endotronix (Woodridge, IL) has developed an integrated platform to provide comprehensive, reimbursable health management innovations for patients suffering from advanced heart failure. The Cordella™ Heart Failure System, includes a cloud-based disease management data system and at-home hemodynamic management with a breakthrough implantable wireless pulmonary artery pressure sensor for early detection of worsening heart failure.

Femeda (Cramlington, United Kingdom) has developed a device for the treatment of weak pelvic floor muscles to improve bladder control in female urinary incontinence.

FineHeart (Pessac, France) The patented FineHeart invention, the ICOMS (Implantable Cardiac Output Management System) is a novel, wirelessly powered, fully implantable mechanical circulatory support device able to optimize cardiac output while preserving the heart’s innate contractility. It is a game-changing therapy for long term circulatory assistance in severe heart failure patients.

Galen Robotics (San Jose, CA) is bringing to market a cooperative robotic platform designed for high precision microsurgery, based on 5 yrs of research and development out of Johns Hopkins University Robotics Lab.  The Galen robot is designed for microsurgical procedures, robotically assisting procedures for ENT, Spine and Neurosurgery through tremor cancellation, tool guidance and stabilization, recordable tool movement and safety barriers.

GraftWorx (Menlo Park, CA) – Medicine today is characterized by clinicians looking retrospectively at diagnostic imaging and laboratory data, which results in expensive, reactionary procedures. GraftWorx is turning the Internet of Things into the Internet of the Body by enabling current “dumb” cardiovascular implants to become “smart.” We then leverage our cloud platform to alert clinicians of potential disasters. Our first product (currently in pre-clinical trials) will save 40,000 amputations in the US each year.

HealthBeacon (Dublin, Ireland) is a medication adherence technology company. We develop smart tools for managing medication. The HealthBeacon is a smart sharps bin for patients who self-inject medications at home. It is digitally connected and programmed with a patient’s personal medication schedule, and uses customized reminders to help them start and stay on track with their medication.

Hemovent GmbH (Aachen, Germany) is an emerging medical device company that has developed disruptive technology: the world’s smallest and first self-contained fully portable Extra Corporeal Membrane Oxygenation (ECMO) system that supports or replaces heart and lung function in the event of cardiac and respiratory failure.

iSTAR Medical (Wavre, Belgium) is a clinical-stage, medical technology company focused on the development of novel ophthalmic implants for patients with glaucoma. Its lead product, called MINIject, is a next generation MIGS device, incorporating an implant made of STAR® material, which exhibits outstanding anti-fibrotic and anti-inflammatory properties leading to superior clinical outcomes.

Latch Medical (Dublin, Ireland) is pioneering a revolutionary Engineered Securement Device for catheters that is intuitive, easy to use, will deliver clinical superiority and is highly cost effective.

Loop Medical (Lutri, Switzerland) is developing a needle-free blood collection technology compatible with existing laboratory infrastructure. This venture is supported by Cerba Healthcare and the Bill and Melinda Gates Foundation.

MangoGen Pharma (Quebec, Canada) is developing gene-delivering cardiac stents and wound healing creams.

Medicem (Kladno, Czech Republic), the world leader in bioanalogic hydrogels, is developing two high value premium intraocular lenses that address the large cataract and presbyopia-correcting markets. WIOL-CF is a CE-marked extended-depth-of-focus (EDOF) lens that is expected to be launched in 2018/2019. The team is also developing FSLA-IOL, a femtosecond laser adjustable lens that can be altered post-implantation repeatedly in a non-invasive laser procedure. This product is targeted to unlock the large yet practically untapped elective-presbyopia market.

Mitre Medical (Morgan Hill, CA) is a privately held medical device company developing the Mitral Touch, a patent pending cardiac device that provides a less invasive approach to treat mitral valve regurgitation (MR).

Neuromod Devices (Dublin, Ireland) has developed and patented a bi-modal neuromodulation technology that it is evaluating for neurological disorders including chronic tinnitus, a condition affecting 10% of the adult population and commonly known as ‘ringing in the ears.’

NeuroRecovery Technologies (San Juan Capistrano, CA) is a pre-revenue medical device company formed as a result of technology developed at UCLA, Cal Tech and The University of Louisville. The Southern California based company is developing innovative neuromodulation systems to advance the rehabilitation and recovery of individuals suffering with paralysis.

Newronika SRL (Milan, Italy) restores brain and body functions with innovative technologies. We translate our deep knowledge on biosignal decoding into clinical practice, with the aim of improving treatments, health, and wellness. With our revolutionary brain devices, the patient receives the right stimulation at the right moment, thus becoming able to perform normal daily activities and improve quality of life.

Perimeter Medical Imaging (Toronto, Ontario, Canada) develops, patents, and commercializes advanced surgical imaging tools that allow surgeons, radiologists and pathologists to better assess microscopic tissue structures during surgical procedures.

PhotoniCare (Champaign, IL) has developed a handheld, low-cost imaging platform that uses light to see through tissue. The first product on this platform is a device that can see through the eardrum without cutting it open, addressing management of middle ear infections, one of the world’s most common diseases

Physeon (Schaffhausen, Switzerland) – The Veinplicity™ device addresses the challenges for a successful first attempt peripheral IV cannulation, the most commonly performed medical intervention in the world. By its intended physiological mechanism of increasing the size of the targeted vein and its lumen, successful first stick venous cannulation rate can be significantly improved with Veinplicity™.

PMD Solutions (Cork, Ireland) – RespiraSense is the world’s only continuous respiratory rate monitor. Respiratory rate is the earliest and single most sensitive indicator of patient deterioration, making 6-12 hours timelier intervention possible to improve outcomes.

Polares Medical (Lausanne, Switzerland) is developing a mitral posterior leaflet replacement device to address the underlying cause of mitral regurgitation in both DMR and FMR patients. The company is expecting to be in first-in-man clinical study within 12 months.

Ponce De Leon Pharmaceutical (Dublin, Ireland) is developing a product formulation aimed at postponing the onset of human frailty, and the extension of human healthspan, the healthy years of living.  The company has partnered with The Buck Institute for Research on Aging, and currently is testing its product in animals, with impressive early results.

Promaxo (Rockville, MD) is a medical device company developing and commercializing an office-based and cost effective MRI with cellular level spatial resolution, real time biopsy and treatment tools, and automated software for tissue characterization. The Company’s current focus is on addressing the needs of the prostate cancer market.

ProVerum Medical (Dublin, Ireland) is an early-stage medical device company developing an innovative medical device technology to treat Benign Prostatic Hyperplasia (BPH)

Raydiant Oximetry (Mountain View, CA) has developed a novel fetal monitor that more accurately measures fetal distress.  This technology will improve childbirth related outcomes for expecting mothers and their babies.

Robocath (Rouen, France) designs and develops innovative robotic solutions for improving endovascular procedures. These procedures are carried out to treat vascular diseases, including heart attacks, the leading cause of death worldwide

RSP Systems A/S (Odense, Denmark) is dedicated to improving the health and quality of life of people worldwide through its unique and patented solution for non-invasive diagnostics. The first targeted application is a product line of noninvasive glucose monitors, which will provide diabetic patients with a convenient, pain free alternative to the current invasive solutions.

Sensimed AG (Lausanne, Switzerland) has developed a unique non-invasive soft contact lens-based solution, the SENSIMED Triggerfish®, with the aim of revolutionizing glaucoma management by providing an automated recording of continuous ocular dimensional change over 24 hours

Synergy Disc Replacement (Boulder, CO) – Synergy-Disc is the first and only Total Disc Replacement implant that unifies the needs for sagittal balance and motion into an alignment correcting cervical disc. Proprietary alignment features allow it to be used in patients that do not have a normal alignment. This unique ability makes Synergy-Disc the only viable alternative to fusion in patients with pre-operative alignment problems.

TAS Medical (San Carlos, CA) – Our Trans Abdominal Strap will meet the large unmet need to close ventral hernia defects laparoscopically while providing millions of dollars in savings for healthcare.

VALFIX Medical (Tel-Aviv, Israel) is developing a complete transcatheter annnuloplasty system by recreating the surgical procedure for the treatment of mitral regurgitation (MR). VALFIX technology can be applied to the vast majority of functional and degenerative MR patients worldwide.

Vivior’s (Zurich, Switzerland) sensor technology provides objective behavioral data to support medical experts in offering personalized vision solutions to their patients.